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Kcnmb2tm1.1Clin
Targeted Allele Detail
Nomenclature
Symbol: Kcnmb2tm1.1Clin
Name: potassium large conductance calcium-activated channel, subfamily M, beta member 2; targeted mutation 1.1, Christopher J Lingle
MGI ID: MGI:5694679
Synonyms: beta2floxed, kcnmb2 floxed
Gene: Kcnmb2  Location: Chr3:31902507-32200180 bp, + strand  Genetic Position: Chr3, 15.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:225860
Parent Cell Line:  B6/BLU (ES Cell)
Strain of Origin:  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a loxP site upstream of exon 1 and a second loxP site downstream of exon 1 followed by an FRT-flanked neomycin resistance (neo) cassette which included a third loxP site, downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 1 floxed. (J:225860)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kcnmb2 Mutation:  9 strains or lines available
References
Original:  J:225860 Martinez-Espinosa PL, et al., Knockout of the BK beta2 subunit abolishes inactivation of BK currents in mouse adrenal chromaffin cells and results in slow-wave burst activity. J Gen Physiol. 2014 Oct;144(4):275-95
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/16/2018
MGI 6.11
The Jackson Laboratory