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Tg(Ckm-Chrnd*S262T)40Cgz
Transgene Detail
Nomenclature
Symbol: Tg(Ckm-Chrnd*S262T)40Cgz
Name: transgene insertion 40, Christopher Gomez
MGI ID: MGI:5694343
Synonyms: deltaS6'T
Transgene: Tg(Ckm-Chrnd*S262T)40Cgz  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ckm-Chrnd*S262T)40Cgz expresses 1 gene
 
Mutation detailsThe murine mutant delta subunit of the acetylcholine receptor which has a threonine for serine substitution at position 262 (S262T) of the second transmembrane domain is under the control of the mouse creatine kinase muscle promoter. A neomycin resistance gene was also inserted downstream of the Chrnd cDNA. Four lines were established: 18, 22, 31, and 40. Line 40 has a transgene copy number of about 25 and is the medium expressing line. (J:31221)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:31221 Gomez CM, et al., A transgenic mouse model of the slow-channel syndrome. Muscle Nerve. 1996 Jan;19(1):79-87
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory