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NirepCBA/J
QTL Variant Detail
Nomenclature
QTL variant: NirepCBA/J
Name: noise induced reduction in endocochlear potential; CBA/J
MGI ID: MGI:5692222
QTL: Nirep  Location: unknown  Genetic Position: Chr18, Syntenic
Variant
origin
Strain of Specimen:  CBA/J
Variant
description
Allele Type:    QTL
Inheritance:    Not Specified
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:155891

Neither C57BL/6J nor C57BL/6J.Cast congenic mice undergo endocochlear potential (EP) reduction when exposed to noise whereas CBA/J and CBA/CaJ do. This difference allowed for the mapping of EP in 80 (C57BL/6J X CBA/J) X C57BL/6J backcross mice and in 26 C57BL/6J.CAST congenics. QTL Nirep mapped with Chromosome 18 locus c18.loc8 at 12.5 cM with a LOD 0f 3.57. Suggestive QTL were found in chromosome 5 and chromosome 16.

References
Original:  J:155891 Ohlemiller KK, et al., A major effect QTL on chromosome 18 for noise injury to the mouse cochlear lateral wall. Hear Res. 2010 Feb;260(1-2):47-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory