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Tjp1tm1Sats
Targeted Allele Detail
Summary
Symbol: Tjp1tm1Sats
Name: tight junction protein 1; targeted mutation 1, Sachiko Tsukita
MGI ID: MGI:5692184
Synonyms: Tjp1-, ZO-1 deficient, ZO-1 knockout
Gene: Tjp1  Location: Chr7:64945913-65177529 bp, - strand  Genetic Position: Chr7, 35.02 cM
Alliance: Tjp1tm1Sats page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:222380
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA beta-geo selection cassette replaced part of exon 2 and all of exon 3. Western blot analysis of embryonic extracts confirmed the absence of protein expression in homozygous mutant embryos. (J:222380)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tjp1 Mutation:  66 strains or lines available
References
Original:  J:222380 Katsuno T, et al., Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells. Mol Biol Cell. 2008 Jun;19(6):2465-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory