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QTL Variant Detail
QTL variant: Eeq3FVB/NJ
Name: exercise endurance QTL 3; FVB/NJ
MGI ID: MGI:5691992
QTL: Eeq3  Location: unknown  Genetic Position: Chr14, Syntenic
Strain of Specimen:  FVB/NJ
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


188 (FVB/NJ x C57BL/6J) F2 mice were used to detect QTL for exercise training response. After treadmill training F2 mice were significantly heaver then C57BL/6J mice but were not unlike FVB/NJ. FVB/NJ mice had the highest intrinsic exercise capacity whereas C57BL/6J had the lowest. C57BL/6J had lower post-training work whereas FVB/NJ had higher post training work. These differences allowed for the QTL mapping of these traits. QTL for pre-training work was found on chromosome 14, Eeq3 (LOD 3.72, cM 4.0, nearest marker, rs3689508) and on chromosome 19 Eeq4(LOD 3.63, cM 34.4, nearest marker , rs3679049). Suggestive QTL were found in chromosomes 1,2,3 and 8. For post training work a QTL Etq1 on chromosome 3 was identified (LOD 4.66 , 60 cM , nearest marker rs3687177) and another Etq2 on chromosome 14(LOD 4.99, cM 26.0 nearest marker rs3660830).

Original:  J:153588 Massett MP, et al., Quantitative trait loci for exercise training responses in FVB/NJ and C57BL/6J mice. Physiol Genomics. 2009 Dec 30;40(1):15-22
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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