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Gdap1tm1.2Geno
Targeted Allele Detail
Nomenclature
Symbol: Gdap1tm1.2Geno
Name: ganglioside-induced differentiation-associated-protein 1; targeted mutation 1.2, Genoway
MGI ID: MGI:5690110
Gene: Gdap1  Location: Chr1:17215586-17234495 bp, + strand  Genetic Position: Chr1, 5.21 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224701
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and a FRT flanked neomycin positive selection gene and a loxP site were inserted downstream of exon 1 by homologous recombination. Recombinase mediated recombination removed the neo cassette and exon 1. Western blot analysis confirmed absence of protein. (J:224701)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gdap1 Mutation:  16 strains or lines available
References
Original:  J:224701 Barneo-Munoz M, et al., Lack of GDAP1 induces neuronal calcium and mitochondrial defects in a knockout mouse model of charcot-marie-tooth neuropathy. PLoS Genet. 2015 Apr;11(4):e1005115
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory