Scml2^em2Shnk
Endonuclease-mediated Allele Detail

Summary

• Symbol: Scml2^em2Shnk
• Name: Scm polycomb group protein like 2; endonuclease-mediated mutation 2, Satoshi H Namekawa
• MGI ID: MGI:5690097
• Synonyms: line 431
• Gene: Scml2 Location: ChrX:159865521-160041209 bp, + strand Genetic Position: ChrX, 73.95 cM
• Alliance: Scml2^em2Shnk page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Zinc finger endonucleases were used to generate a knock-out allele. Lines 431 contains a 16 base pair deletion in exon 6. Western blot analysis confirmed the absence of protein expression. (J:225041)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scml2 Mutation: 13 strains or lines available

References

• Original: J:225041 Hasegawa K, et al., SCML2 establishes the male germline epigenome through regulation of histone H2A ubiquitination. Dev Cell. 2015 Mar 9;32(5):574-88
• All: 7 reference(s)