Bod8^LG/J
QTL Variant Detail

Summary

• QTL variant: Bod8^LG/J
• Name: bone length and organs 8; LG/J
• MGI ID: MGI:5690018
• QTL: Bod8 Location: unknown Genetic Position: Chr14, cM position of peak correlated region/allele: 11.53 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: LG/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:109795

Genetic loci associated with long bone length, necropsy body weight, and organ weight were mapped in 1045 animals from a (LG/J x SM/J)F2 intercross. Animals were phenotyped between 70 and 237 days of age, with an average age at sacrifice of 144 days. Twodifferent sets of F2 mice were genotyped for 75 and 96 polymorphic markers across 19 autosomes. 97 single trait QTL were identified. After pleiotropy analysis the 97 loci coalesced into 35 pleiotropic QTLs. Cutoff for statistical significance is LPR=3.49but all pleiotropic loci listed in the reference are reported here.

On mouse Chromosome 14, Bod8 (bone length and organs 8) was detected at 24 cM near D14Nds1 (LPR=4.11). This locus is associated with necropsy body weight, liver, heart, and kidney weights, and femur and ulna lengths. Bod8 association with humerus length is male-specific. The Bod8 confidence interval spans 6 cM - 32 cM. Previously identified QTL Wta3 (3 cM) may be identical to Bod8. Potential candidate genes include Hesx1, Wnt5a (7.8 cM), Pb1, Gdf10 (13 cM), Bmpr1a (13 cM), Nrg3, and Bmp4 (15 cM).

References

• Original: J:109795 Kenney-Hunt JP, et al., Quantitative trait loci for body size components in mice. Mamm Genome. 2006 Jun;17(6):526-37
• All: 1 reference(s)