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QTL Variant Detail
QTL variant: Lacanx4C58/J
Name: locomotor activation and anxiety 4; C58/J
MGI ID: MGI:5689595
QTL: Lacanx4  Location: unknown  Genetic Position: Chr13, Syntenic
Strain of Specimen:  C58/J
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


The authors mapped QTLs associated with locomotor activation and anxiety using 196 female and 166 male F2 mice. The F2 mice were derived from a (C57BL/6J x C58/J)F1 cross and genotyped using a panel of 211 SNP markers, yielding an average SNP density of one marker per 11 mega base pairs. A significant QTL on mouse Chromosome 8 (Lacanx1) is associated with multiple behaviors, including total distance (LOD = 4.1, peak 49 Mb), ambulatory episodes (LOD = 3.8, peak 62 Mb), percent time resting (LOD = 3.5, peak 89 Mb) and average velocity (LOD = 3.3, peak 78 Mb). Two additional QTL that associate with multiple phenotypes were identified. A locus on mouse Chromosome 6 (Lacanx 2)is significant for total distance (LOD = 3.3, peak 47 Mb) and suggestive for both ambulatory episodes (LOD = 2.7, peak 49 Mb) and percent time resting (LOD = 2.8, peak 49 Mb). A QTL on mouse Chromosome 1 (Lacanx 3) (LOD = 3.3, peak 160 Mb) is significantly associated with percent time spent in the center of the open field and suggestive for average velocity (LOD = 2.6, peak 160 Mb).QTL loci that were alsofound to associate with multiple measures, a significant QTL was also identified on mouse Chromosome 13( Lacanx 4) (LOD = 3.6, peak 77 Mb) that associates specifically with percent time spent in the center of the open field.

Original:  J:151136 Bailey JS, et al., Identification of quantitative trait loci for locomotor activation and anxiety using closely related inbred strains. Genes Brain Behav. 2008 Oct;7(7):761-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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