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Del(16Kcnj15-Mx2)13Yey
Targeted Allele Detail
Nomenclature
Symbol: Del(16Kcnj15-Mx2)13Yey
Name: deletion, Chr 16, Y Eugene Yu 13
MGI ID: MGI:5689439
Synonyms: Df(16)6, Df(16)6Yey
Gene: Del(16Kcnj15-Mx2)13Yey  Location: unknown  Genetic Position: Chr16, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224899
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion, Intragenic deletion
  Del(16Kcnj15-Mx2)13Yey involves 16 genes/genome features (Kcnj15, Erg, Ets2 ...) View all
 
Mutation detailshromosome-engineering cassettes were inserted into mouse Chromosome 16 to bracket a span between the potassium inwardly-rectifying channel, subfamily J, member 15 (Kcnj15) gene and the MX dynamin-like GTPase 2 (Mx2) gene. The cassette placed at the proximal locus (MICER clone MHPP54c08) was targeted upstream of Kcnj15 and contained a neomycin resistance gene, a loxP site, a 5' portion of an HPRT minigene, and a tyrosinase minigene. The cassette placed at the distal locus (MICER clone MHPN178b08) was targeted downstream of the Mx2 gene and contained an agouti transgene, a 3' portion of an HPRT minigene, a loxP site and puromycin resistance gene. Double-targeted ES cells were transiently transfected with the cre recombinase expression vector pOG231 to remove the region from Kcnj15 to Mx2, which encompasses 16 genes. FISH analysis of ES cell clones confirmed the deletions. (J:224899)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Del(16Kcnj15-Mx2)13Yey Mutation:  1 strain or line available
References
Original:  J:224899 Jiang X, et al., Genetic dissection of the Down syndrome critical region. Hum Mol Genet. 2015 Nov 15;24(22):6540-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory