Tg(LONP1-mt-ND4*,-mCherry*)#Jguy
Transgene Detail
|
Symbol: |
Tg(LONP1-mt-ND4*,-mCherry*)#Jguy |
Name: |
transgene, John Guy |
MGI ID: |
MGI:5689425 |
Synonyms: |
mutND4, sc-HSP-mutantND4FLAG-mt-mCherry |
Transgene: |
Tg(LONP1-mt-ND4*,-mCherry*)#Jguy Location: unknown
|
Alliance: |
Tg(LONP1-mt-ND4*,-mCherry*)#Jguy page
|
|
|
Transgene Type: |
|
Transgenic (Epitope tag, Inserted expressed sequence, Reporter) |
Mutation: |
|
Insertion
|
|
|
Tg(LONP1-mt-ND4*,-mCherry*)#Jguy expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
ND4 (4538) |
|
|
|
|
|
Mutation details: The mitochondria-targeted self-complementary adeno-associated virus (AAV) transgene contained the human mitochondrial heavy-strand promoter driving mitochondrial expression of the FLAG tagged human mt-ND4 with the substitution of A for G taht results in an arginine-to-histidine substitution and mitochondrial mCherry with the substitution A for C. This mutation is responsible for Leber hereditary optic neuropathy (LHON). There are two stop codons between the genes. The pound symbol (#) is used when no line is specified and/or lines are pooled.
(J:224897)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
The transgene is maintained without integration into the host genome.
|
Original: |
J:224897 Yu H, et al., Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice. Proc Natl Acad Sci U S A. 2015 Oct 20;112(42):E5689-98 |
All: |
1 reference(s) |
|