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Pkn3tm1.2Mrl
Targeted Allele Detail
Nomenclature
Symbol: Pkn3tm1.2Mrl
Name: protein kinase N3; targeted mutation 1.2, Merck Research Laboratory
MGI ID: MGI:5688856
Synonyms: Pkn3-
Gene: Pkn3  Location: Chr2:30077684-30091022 bp, + strand  Genetic Position: Chr2, 21.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216983
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and FRT flanked beta-geo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the beta-geo cassette and exons 2-6. (J:216983)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkn3 Mutation:  31 strains or lines available
References
Original:  J:216983 Kraus M, et al., Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. Leukemia. 2015 Jan;29(1):255-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory