Pkn3^tm1.2Mrl
Targeted Allele Detail

Summary

• Symbol: Pkn3^tm1.2Mrl
• Name: protein kinase N3; targeted mutation 1.2, Merck Research Laboratory
• MGI ID: MGI:5688856
• Synonyms: Pkn3^-
• Gene: Pkn3 Location: Chr2:29967696-29981034 bp, + strand Genetic Position: Chr2, 21.13 cM
• Alliance: Pkn3^tm1.2Mrl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216983
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked beta-geo cassette were inserted upstream of exon 2 and a loxP site was inserted downstream of exon 6 via homologous recombination. Recombinase mediated recombination removed the beta-geo cassette and exons 2-6. (J:216983)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pkn3 Mutation: 54 strains or lines available

References

• Original: J:216983 Kraus M, et al., Protein kinase N3 deficiency impedes PI3-kinase pathway-driven leukemogenesis without affecting normal hematopoiesis. Leukemia. 2015 Jan;29(1):255-8
• All: 1 reference(s)