About   Help   FAQ
Itgb3tm1.1Wlbcr
Targeted Allele Detail
Nomenclature
Symbol: Itgb3tm1.1Wlbcr
Name: integrin beta 3; targeted mutation 1.1, Katherine Weilbaecher
MGI ID: MGI:5688572
Synonyms: B3flox, beta3flox
Gene: Itgb3  Location: Chr11:104608000-104670476 bp, + strand  Genetic Position: Chr11, 67.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:224675
Parent Cell Line:  B6/BLU (ES Cell)
Strain of Origin:  C57BL/6NTac-Tg(HBB-lacZ)ALey/Ley
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting vector was designed to insert a single loxP site upstream of exon 1 and loxP-flanked PGK-neomycin resistance (neo) cassette downstream of exon 1. The neo cassette was deleted by transiently transfection of a pTURBO-Cre expression plasmid leaving exon 1 floxed. (J:224675)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itgb3 Mutation:  30 strains or lines available
Notes
B6/BLU embryonic stem cells contain a LacZ reporter fused to beta-globin and is expressed in peripheral blood cells.
References
Original:  J:224675 Morgan EA, et al., Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit. FASEB J. 2010 Apr;24(4):1117-27
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2020
MGI 6.15
The Jackson Laboratory