Tg(SFTPC-Il18)AThos
Transgene Detail

Summary

• Symbol: Tg(SFTPC-Il18)AThos
• Name: transgene insertion A, Tomoaki Hoshino
• MGI ID: MGI:5688493
• Synonyms: SPC-IL-18 Tg
• Transgene: Tg(SFTPC-Il18)AThos Location: unknown
• Alliance: Tg(SFTPC-Il18)AThos page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(SFTPC-Il18)AThos expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Il18 (MGI:107936)

• Mutation details: The human surfactant protein C promoter drives the expression of the mouse mature Il18 cDNA fused with the signal peptide from the v-J2-C region of the mouse Igmu-chain in alveolar and bronchiolar epithelial cells. Western blot analysis confirmed expression in the lungs but not other tissues. Four founders were established: A, B, C, and D. Line A is a representative line as lines A, B, and C exhibit similar phenotypes. (J:147547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:147547 Hoshino T, et al., Pulmonary inflammation and emphysema: role of the cytokines IL-18 and IL-13. Am J Respir Crit Care Med. 2007 Jul 1;176(1):49-62
• All: 2 reference(s)