Ath42^{B6.129P2-Apoe-tm1Unc/J}
QTL Variant Detail

Summary

• QTL variant: Ath42^{B6.129P2-Apoe-tm1Unc/J}
• Name: atherosclerosis 42; B6.129P2-Apoe^tm1Unc/J
• MGI ID: MGI:5661856
• QTL: Ath42 Location: unknown Genetic Position: Chr5, Syntenic

Variant origin

• Strain of Specimen: B6.129P2-Apoe^tm1Unc/J

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:187953

Linkage analysis was performed on 266 female (B6.129P2-Apoe^tm1Unc/J x C.129P2(B6)-Apoe^tm1Unc)F2 intercross mice using 130 SNP markers to identify QTL associated with atherosclerotic susceptibility (atherosclerotic lesion size at aortic root). Parental strain B6.129P2-Apoe^tm1Unc/J exhibits higher incidence of atherosclerosis when compared to C.129P2(B6)-Apoe^tm1Unc.

QTL Ath42 maps to 48.5 - 60.7 cM on Chromosome 5 with a peak LOD score of 5.69 at D5mit41 (54.7 cM) in linkage with atherosclerotic lesion size. B6.129P2-Apoe^tm1Unc/J alleles confer increased susceptibility to atherosclerotic lesion size with a dominant mode of inheritance.

References

• Original: J:187953 Zhang Z, et al., Genetic analysis of atherosclerosis and glucose homeostasis in an intercross between C57BL/6 and BALB/cJ apolipoprotein E-deficient mice. Circ Cardiovasc Genet. 2012 Apr 1;5(2):190-201
• All: 1 reference(s)