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QTL Variant Detail
QTL variant: Pgia42BALB/cCrl
Name: proteoglycan induced arthritis 42; BALB/cCrl
MGI ID: MGI:5661421
QTL: Pgia42  Location: unknown  Genetic Position: Chr19, Syntenic
Strain of Specimen:  BALB/cCrl
Allele Type:    QTL

Mapping and Phenotype information for this QTL, its variants and associated markers


Linkage analysis at an average resolution of 10 cM was performed on 3 separate mouse crosses to map QTLs associated with proteoglycan-induced arthritis (PGIA) and collagen-induced arthritis (CIA).

559 (BALB/c x DBA/2)F2 MHC-matched animals and 402 (BALB/c x DBA/1J)F2 MHC-unmatched animals were analyzed for linkage to PGIA.

537 (BALB/c x DBA/1J)F2 animals were analyzed for linkage to CIA. With respect to PGIA, parental strain BALB/c is highly susceptible whereas parental strains DBA/2 and DBA/1J are fullyresistant. As expected, (BALB/c x DBA/2)F1 hybrids are resistant to PGIA, but interestingly (BALB/c x DBA/1J)F1 hybrids are susceptible to PGIA. This is unusual because the BALB/c allele typically exhibits recessive susceptibility to disease, but thisisnot the case with the cross to DBA/1J.

With respect to CIA, parental strain DBA/1J is highly susceptible whereas parental strains BALB/c and DBA/2 are fully resistant. All F1s exhibited susceptibility to CIA.

Pgia23 mapped to proximal mouse Chromosome 19 in association with PGIA susceptibility (LOD=3.5) in the MHC-unmatched (BALB/c x DBA/1J)F2 population. Pgia23 overlaps with Cia12.

9.10.2015 - Curators Note: The distal QTL on Chr 19 linked with severity is referred to as Pgia12 within the text. However, since Pgia12 was originally mapped in J:66460 in 1999 using a (BALB/cCrl x DBA/2Crl)F2 cross, which differs from the cross used here ((BALB/c x DBA/1J)F2), we consider the current study a separate mapping study and have name the QTL Pgia42.

Pgia42 mapped to distal mouse Chromosome 19 in association with PGIA severity (LOD=4.5) in the MHC-unmatched (BALB/c x DBA/1J)F2 population.

Original:  J:89536 Glant TT, et al., Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis. Am J Med Sci. 2004 Apr;327(4):188-95
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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