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Nphs1tm1Afrn
Targeted Allele Detail
Nomenclature
Symbol: Nphs1tm1Afrn
Name: nephrosis 1, nephrin; targeted mutation 1, Alessia Fornoni
MGI ID: MGI:5661391
Synonyms: NPflox
Gene: Nphs1  Location: Chr7:30458315-30487223 bp, + strand  Genetic Position: Chr7, 18.36 cM, cytoband A3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:261848
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThe targeting vector is designed to insert one loxP site upstream of exon 1B, one loxP site upstream of exon 1A, and an FRT-flanked polyA site and a neomycin resistance (neo) cassette followed by a third loxP site downstream of exon 5. (J:261848)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nphs1 Mutation:  50 strains or lines available
References
Original:  J:261848 Villarreal R, et al., Nephrin Contributes to Insulin Secretion and Affects Mammalian Target of Rapamycin Signaling Independently of Insulin Receptor. J Am Soc Nephrol. 2016 Apr;27(4):1029-41
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory