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Agltm1Geno
Targeted Allele Detail
Nomenclature
Symbol: Agltm1Geno
Name: amylo-1,6-glucosidase, 4-alpha-glucanotransferase; targeted mutation 1, Genoway
MGI ID: MGI:5661387
Gene: Agl  Location: Chr3:116739999-116808166 bp, - strand  Genetic Position: Chr3, 50.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:218471
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 32-34 (coding for the last 114 amino acids) were replaced with a loxP flanked neomycin resistance cassette. This deletes the carboxy terminus, including the glucosidase and glycogen-binding domains. Western blot analysis confirmed absence of protein in all tissues analyzed. (J:218471)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Agl Mutation:  7 strains or lines available
References
Original:  J:218471 Pagliarani S, et al., Glycogen storage disease type III: A novel Agl knockout mouse model. Biochim Biophys Acta. 2014 Nov;1842(11):2318-28
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory