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Tg(Myh6-Jup*)1Ajm
Transgene Detail
Nomenclature
Symbol: Tg(Myh6-Jup*)1Ajm
Name: transgene insertion 1, Ali J Marian
MGI ID: MGI:5660496
Synonyms: PGTR
Transgene: Tg(Myh6-Jup*)1Ajm  Location: unknown  
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Myh6-Jup*)1Ajm expresses 1 gene
 
Mutation detailsA truncated murine plakoglobin gene is under the control of the cardiac-restricted alpha-myosin heavy chain promoter. To generate the truncated gene, a 2 base pair deletion was introduced which causes a frameshift at the 3' end of the Jup gene and introduces 11 new amino acids, and a stop codon was introduced after the 11 new amino acids. Three lines were generated: 1, 2, and 3. Line 1 is the high-expressing line. (J:192719)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:192719 Lombardi R, et al., Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy. Circ Res. 2011 Dec 9;109(12):1342-53
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory