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Dcntm1.2Geno
Targeted Allele Detail
Nomenclature
Symbol: Dcntm1.2Geno
Name: decorin; targeted mutation 1.2, Genoway
MGI ID: MGI:5660397
Gene: Dcn  Location: Chr10:97479609-97518143 bp, + strand  Genetic Position: Chr10, 50.27 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:223791
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe targeting vector is designed to insert a loxP site upstream of exon 8, and a FRT-flanked neomycin resistance cassette followed by a second loxP site downstream of exon 8. Exon 8 also contains a 952delT mutation that corresponds to the 967delT human mutation associated with autosomal dominant congenital stromal corneal dystrophy (CSCD). Flp-mediated recombination removed the FRT-flanked neo cassette and cre-mediated recombination removed exon 8. (J:223791)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dcn Mutation:  11 strains or lines available
References
Original:  J:223791 Mellgren AE, et al., Development of congenital stromal corneal dystrophy is dependent on export and extracellular deposition of truncated decorin. Invest Ophthalmol Vis Sci. 2015 May;56(5):2909-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory