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Hmox1tm1.1Hes
Targeted Allele Detail
Nomenclature
Symbol: Hmox1tm1.1Hes
Name: heme oxygenase 1; targeted mutation 1.1, Harald Esterbauer
MGI ID: MGI:5649369
Synonyms: HO-1fl
Gene: Hmox1  Location: Chr8:75093621-75100589 bp, + strand  Genetic Position: Chr8, 35.59 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:214639
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette leaving exon 2 floxed. (J:214639)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmox1 Mutation:  10 strains or lines available
References
Original:  J:214639 Jais A, et al., Heme oxygenase-1 drives metaflammation and insulin resistance in mouse and man. Cell. 2014 Jul 3;158(1):25-40
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory