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Targeted Allele Detail
Symbol: Mirc1tm2.1Aven
Name: microRNA cluster 1, including Mir17 through Mir92-1; targeted mutation 2.1, Andrea Ventura
MGI ID: MGI:5648458
Synonyms: miR-17~92 delta19
Gene: Mirc1  Location: Chr14:115281103-115281938 bp  Genetic Position: Chr14, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:223213
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intergenic deletion
  Mirc1tm2.1Aven involves 2 genes/genome features (Mir19a, Mir19b-1) View all
Mutation detailsThe Mir19a and Mir19b-1 genes were replaced by an FRT-flanked neomycin cassette. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:223213)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 155937 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mirc1 Mutation:  6 strains or lines available
Original:  J:223213 Han YC, et al., An allelic series of miR-17 approximately 92-mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat Genet. 2015 Jul;47(7):766-75
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory