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Transgene Detail
Symbol: Tg(Tcra6C2,Tcrb6C2)16Chi
Name: transgene insertion 16, Francis Chisari
MGI ID: MGI:5648206
Synonyms: Env28 TCR transgenic
Transgene: Tg(Tcra6C2,Tcrb6C2)16Chi  Location: unknown  
Strain of Origin:  BALB/cByJ or C57BL/6J
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Tcra6C2,Tcrb6C2)16Chi expresses 2 genes
Mutation detailsRearranged Valpha4.1 JalphaNEW and Vbeta1.1 Jbeta2.5 sequences are obtained from L-restricted CD3<+> CD4<-> CD8<+> cytotoxic T lymphocytes (clone 6C2), which recognizes an epitope located between residues 28-39 of HBsAg. These TCR sequences were cloned into TCR cassette expression vectors (pTalpha and pTbeta), and co-injected. The primary investigator indicates that cells from founder lines 16 and 36 exhibit no differences in epitope recognition. (J:213364)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
TCR expression cassettes into which the TCRalpha and TCRbeta cDNA sequences had been cloned were co-injected into (BALB/cByJ x C57BL/6J)F2 fertilized oocytes.
Original:  J:213364 Isogawa M, et al., CD40 activation rescues antiviral CD8(+) T cells from PD-1-mediated exhaustion. PLoS Pathog. 2013;9(7):e1003490
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory