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Abcc9tm1.1Mcn
Targeted Allele Detail
Nomenclature
Symbol: Abcc9tm1.1Mcn
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 9; targeted mutation 1, Elizabeth M McNally
MGI ID: MGI:5646147
Gene: Abcc9  Location: Chr6:142587862-142702315 bp, - strand  Genetic Position: Chr6, 74.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:216539
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites and a neomycin selection cassette were inserted into the flanking regions of exon 5. Mice heterozygous for the targeted allele were crossed with protamine-Cre transgenic mice to remove the neomycin cassette and exon 5. Deletion of exon 5 induced a frameshift and disrupted expression of the encoded protein. Expression of both the long form and the short form of the encoded protein was affected. (J:216539)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc9 Mutation:  4 strains or lines available
References
Original:  J:216539 Fahrenbach JP, et al., Abcc9 is required for the transition to oxidative metabolism in the newborn heart. FASEB J. 2014 Jul;28(7):2804-15
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory