F13a1^tm1Akic
Targeted Allele Detail

Summary

• Symbol: F13a1^tm1Akic
• Name: coagulation factor XIII, A1 subunit; targeted mutation 1, Akitada Ichinose
• MGI ID: MGI:5645817
• Gene: F13a1 Location: Chr13:37051152-37234220 bp, - strand Genetic Position: Chr13, 14.44 cM
• Alliance: F13a1^tm1Akic page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:222849
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment including all of exon 7 was replaced with a neo cassette via homologous recombination. Northern and western blot analysis confirmed the absence of mRNA and protein expression in homozygous mice. Expression of F13b was reduced to less than 20% of wild-type in homozygous mice. (J:222849)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F13a1 Mutation: 47 strains or lines available

References

• Original: J:222849 Souri M, et al., Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Int J Hematol. 2008 Jan;87(1):60-8
• All: 7 reference(s)