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Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu
Transgene Detail
Nomenclature
Symbol: Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu
Name: transgene insertion 682, Gang Yu
MGI ID: MGI:5644691
Transgene: Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu  Location: unknown  
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu/0 Meox2tm1(cre)Sor/Meox2+ mice display hindlimb curl

Show the 5 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  C57BL/6J
Transgene
description
Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu expresses 1 gene
 
Mutation detailsThis transgene consists of the cytomegalovirus immediate early enhancer-chicken beta-actin hybrid (CAG) promoter, a floxed lacZ gene, human FUS cDNA with the R521C mutation, IRES, and EGFP coding sequences. Cre-excision of the loxP flanked lacZ DNA allows for translation of FUS and EGFP. Two lines were generated: 673, and 682. Line 682 was chosen as a representative line. (J:216672)
Generation of the Tg(CAG-lacZ,-FUS,-EGFP)629Gyu and Tg(CAG-lacZ,-FUS*R521G,-EGFP)682Gyu transgenes
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:216672 Sephton CF, et al., Activity-dependent FUS dysregulation disrupts synaptic homeostasis. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):E4769-78
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory