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Tg(H2-Kb-Tcra,-Tcrb)1640Kurs
Transgene Detail
Nomenclature
Symbol: Tg(H2-Kb-Tcra,-Tcrb)1640Kurs
Name: transgene insertion 1640, Florian C Kurschus
MGI ID: MGI:5644514
Synonyms: RR mouse, TCR1640
Transgene: Tg(H2-Kb-Tcra,-Tcrb)1640Kurs  Location: unknown  
Severe infiltration, demyelination, and axonal damage in Tg(H2-Kb-Tcra,-Tcrb)1640Kurs/0 cerebellum and spinal cord

Show the 2 phenotype image(s) involving this allele.

Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(H2-Kb-Tcra,-Tcrb)1640Kurs expresses 2 genes
 
Mutation detailsThis transgene consists of a T-cell antigen receptor (TCR) that recognizes rat/mouse MOG peptide 92-106 bound to I-AS under the control of the MHC class I H2-Kb promoter. The TCR uses Valpha8.3 and Vbeta4 genes derived from a MOG-specific encephalitogenic Th1-CD4+ T cell clone isolated from a wild-type SJL/J mouse immunized against recombinant rat Mog. Three founder lines were established, differing in distinct proportions of transgenic Valpha8.3+/Vbeta4+ CD4+ T cells in central and peripheral immune repertoires. In the high frequency line 1640, 99% of single-positive CD4+CD8- thymocytes express the transgenic TCR. (J:149511)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:149511 Pollinger B, et al., Spontaneous relapsing-remitting EAE in the SJL/J mouse: MOG-reactive transgenic T cells recruit endogenous MOG-specific B cells. J Exp Med. 2009 Jun 8;206(6):1303-16
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory