About   Help   FAQ
Tbptm1Xjl
Targeted Allele Detail
Nomenclature
Symbol: Tbptm1Xjl
Name: TATA box binding protein; targeted mutation 1, Xiao-Jiang Li
MGI ID: MGI:5644074
Synonyms: TBP-105 glutamineloxp
Gene: Tbp  Location: Chr17:15499888-15517427 bp, + strand  Genetic Position: Chr17, 8.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221703
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 2 was replaced with a floxed STOP, a neomycin resistance cassette and the corresponding human sequence for exon 2 with 105 CAG repeats. (J:221703)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbp Mutation:  10 strains or lines available
References
Original:  J:221703 Huang S, et al., Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain. 2011 Jul;134(Pt 7):1943-58
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/10/2019
MGI 6.14
The Jackson Laboratory