About   Help   FAQ
Slc6a3tm1Rbl
Targeted Allele Detail
Nomenclature
Symbol: Slc6a3tm1Rbl
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Randy D Blakely
MGI ID: MGI:5643943
Synonyms: DAT Val559
Gene: Slc6a3  Location: Chr13:73536747-73578672 bp, + strand  Genetic Position: Chr13, 40.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:221936
Parent Cell Line:  TL1/TL-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA valine for alanine substitution at amino acid 559 (A559V, equivalent to that found in ADHD probands) was introduced in exon 13, along with a self-excising loxP-flanked cre recombinase and neomycin resistance cassettes in the 3 intron. (J:221936)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:  47 strains or lines available
References
Original:  J:221936 Mergy MA, et al., Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: on the path to an animal model of attention-deficit hyperactivity disorder. Neurochem Int. 2014 Jul;73:56-70
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/14/2020
MGI 6.14
The Jackson Laboratory