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Targeted Allele Detail
Symbol: Fgd5tm1Djr
Name: FYVE, RhoGEF and PH domain containing 5; targeted mutation 1, Derrick Rossi
MGI ID: MGI:5642321
Synonyms: Fgd5mCherry
Gene: Fgd5  Location: Chr6:91978878-92076004 bp, + strand  Genetic Position: Chr6, 41.0 cM
Germline Transmission:  Earliest citation of germline transmission: J:214520
Parent Cell Line:  ART B6-3, B6-3 (ES Cell)
Strain of Origin:  C57BL/6NTac
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsThe targeting vector consists of an mCherry cassette followed by an FRT-flanked neomycin cassette inserted in frame into exon 1. mCherry expression is almost exclusively specific to bone marrow hematopoietic stem cells, with some low level of expression detected in bone marrow multipotent progenitor cells. (J:214520)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgd5 Mutation:  28 strains or lines available
Original:  J:214520 Gazit R, et al., Fgd5 identifies hematopoietic stem cells in the murine bone marrow. J Exp Med. 2014 Jun 30;211(7):1315-31
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory