Albq19^MRL/MpJ
QTL Variant Detail

Summary

• QTL variant: Albq19^MRL/MpJ
• Name: albuminuria QTL 19; MRL/MpJ
• MGI ID: MGI:5642008
• QTL: Albq19 Location: Chr4:129824389-129824389 bp Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: MRL/MpJ

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:175511

Linkage analysis was performed on 371 male (MRL/MpJ x SM/J)F2 intercross mice using 258 SNP markers to identify QTL associated with urinary albumin-to-creatinine ratio (ACR). Parental strain SM/J exhibits higher urinary ACR when compared to MRL/MpJ.

QTL Albq19 maps to 61.8 - 131.8 Mb on Chromosome 4 with a peak LOD score of 5.6 at 53 cM (rs3661158) in linkage with urinary ACR. SM/J alleles confer likelyhood of increased urinary ACR.

References

• Original: J:175511 Hageman RS, et al., Uncovering genes and regulatory pathways related to urinary albumin excretion. J Am Soc Nephrol. 2011 Jan;22(1):73-81
• All: 1 reference(s)