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Tgfbitm1Jwu
Targeted Allele Detail
Nomenclature
Symbol: Tgfbitm1Jwu
Name: transforming growth factor, beta induced; targeted mutation 1, Jiangping Wu
MGI ID: MGI:5638662
Gene: Tgfbi  Location: Chr13:56609586-56639359 bp, + strand  Genetic Position: Chr13, 30.09 cM, cytoband B-C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:213611
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 - 11 were replaced with a neo cassette via homologous recombination. RT-QPCR and ELISA analysis confirmed the absence of expression in tissues from homozygous mutant mice. (J:213611)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbi Mutation:  1 strain or line available
References
Original:  J:213611 Han B, et al., TGFBI (betaIG-H3) is a diabetes-risk gene based on mouse and human genetic studies. Hum Mol Genet. 2014 Sep 1;23(17):4597-611
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory