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Targeted Allele Detail
Symbol: Nmstm1.1Ywa
Name: neuromedin S; targeted mutation 1.1, Masashi Yanagisawa
MGI ID: MGI:5638422
Gene: Nms  Location: Chr1:38978230-38989357 bp, + strand  Genetic Position: Chr1, 17.31 cM
Germline Transmission:  Earliest citation of germline transmission: J:219926
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector containing an FRT-flanked PGK-NEO cassette, a DTA cassette and a Cre recombinase cassette are used to replace the start codon in exon 1 and 59 bp of signal peptide sequence at the ATG start codon. Flp-mediated recombination removed the FRT-flanked neo cassette. Immunostaining analysis of the suprachiasmatic nucleus does not detect a gene product. The investigator reports that the Cre recombinase cassette is non-functional or very minimally functional. (J:219926)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nms Mutation:  14 strains or lines available
Original:  J:219926 Lee IT, et al., Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. Neuron. 2015 Mar 4;85(5):1086-102
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
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