About   Help   FAQ
Apptm3.1Tcs
Targeted Allele Detail
Nomenclature
Symbol: Apptm3.1Tcs
Name: amyloid beta (A4) precursor protein; targeted mutation 3.1, Takaomi C Saido
MGI ID: MGI:5637817
Synonyms: AppNL-G-F
Gene: App  Location: Chr16:84751236-84972187 bp, - strand  Genetic Position: Chr16, 46.92 cM, cytoband C3-qter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212758
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
 
Mutation detailsThe sequence of exon 16 was humanized and the Swedish mutations (KM670/671NL) were introduced, the Arctic (E22G) and Beyreuther/Iberian mutations (I716F) were inserted into exon 17 and a floxed neo cassette was inserted in intron 16 via homologous recombination. Cre mediated recombination removed the neo cassette. (J:212758)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any App Mutation:  65 strains or lines available
References
Original:  J:212758 Saito T, et al., Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci. 2014 May;17(5):661-3
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/07/2021
MGI 6.17
The Jackson Laboratory