Slc22a1^tm1Kmgi
Targeted Allele Detail

Summary

• Symbol: Slc22a1^tm1Kmgi
• Name: solute carrier family 22 (organic cation transporter), member 1; targeted mutation 1, Kathleen M Giacomini
• MGI ID: MGI:5636771
• Synonyms: Oct1^-
• Gene: Slc22a1 Location: Chr17:12867756-12894716 bp, - strand Genetic Position: Chr17, 8.63 cM
• Alliance: Slc22a1^tm1Kmgi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122106
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: A splice acceptor-IRES-lacZ neo cassette replaced a genomic region encompassing all of exons 3 - 5 and parts of exons 2 and 6. (J:122106)

Generation of Slc22a1^tm1Kmgi allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc22a1 Mutation: 29 strains or lines available

References

• Original: J:122106 Shu Y, et al., Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest. 2007 May;117(5):1422-31
• All: 3 reference(s)