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Jckm4FVB
QTL Variant Detail
Summary
QTL variant: Jckm4FVB
Name: juvenile cystic kidney modifier 4; FVB
MGI ID: MGI:5636765
QTL: Jckm4  Location: Chr1:133290836-133290937 bp  Genetic Position: Chr1, Syntenic
Variant
origin
Strain of Specimen:  FVB
Variant
description
Allele Type:    QTL
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:59425

The existence of two QTLs that modify the severity of polycystic kidney disease (PKD) in jck mice was indicated. One such marker identified as Jckm2 mapped significantly with D1Mit30 on mouse Chromosome 1 as evidenced in progeny from a (C57BL/6J jck/jck x FVB)F1 jck/+ intercross with an associated LOD score given as 4.1 . The other modifying marker was indicated as Jckm1 and mapped with D10Mit20 with a LOD score of 3.5. Moreover, various congenic strains were constructed that supported the existence of these two modifying loci. Another report detailing the QTL mapping of Jckm1 and Jckm2 can be found in J:23893.

04/15/2015 Curator Note: Because Jckm1 and Jckm2 were originally mapped in J:23893 in 1995 using an (C57BL/6J x DBA/2J)F1 jck /+ intercross,which differs from the cross used here, we consider the current study a separate mapping experiment and have named these QTL Jckm3 (Chr 10) and Jckm4 (Chr 1) respectively.

References
Original:  J:59425 Iakoubova O, et al., Genetic analysis of modifying loci on mouse chromosome 1 that affect disease severity in a model of recessive PKD. Physiol Genomics. 1999 Aug 31;1(2):101-5
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory