Mau2^tm1.2Hpt
Targeted Allele Detail

Summary

• Symbol: Mau2^tm1.2Hpt
• Name: MAU2 sister chromatid cohesion factor; targeted mutation 1.2, Heiko Peters
• MGI ID: MGI:5636690
• Synonyms: Mau2^-, Mau2^deltaE10-12
• Gene: Mau2 Location: Chr8:70468773-70495384 bp, - strand Genetic Position: Chr8, 34.15 cM, cytoband C1
• Alliance: Mau2^tm1.2Hpt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:213338
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 10. An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the selection cassette and left exons 10 through 12 floxed. Cre-mediated recombination removed exons 10 through 12. (J:213338)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mau2 Mutation: 33 strains or lines available

References

• Original: J:213338 Smith TG, et al., Neural crest cell-specific inactivation of Nipbl or Mau2 during mouse development results in a late onset of craniofacial defects. Genesis. 2014 Jul;52(7):687-94
• All: 1 reference(s)