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Targeted Allele Detail
Symbol: Ndrg2tm1.1Hori
Name: N-myc downstream regulated gene 2; targeted mutation 1.1, Osamu Hori
MGI ID: MGI:5636684
Synonyms: Ndrg2-
Gene: Ndrg2  Location: Chr14:51905271-51914004 bp, - strand  Genetic Position: Chr14, 26.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:214686
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 4. Cre-mediated recombination removed the selection cassette along with exons 3 and 4. RT-PCR and Western blot analysis confirmed absence of mRNA and protein expression in the brain, liver, and heart from homozygous mutant mice. (J:214686)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ndrg2 Mutation:  2 strains or lines available
Original:  J:214686 Takarada-Iemata M, et al., Deletion of N-myc downstream-regulated gene 2 attenuates reactive astrogliosis and inflammatory response in a mouse model of cortical stab injury. J Neurochem. 2014 Aug;130(3):374-87
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory