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Tg(TRATL3A6,TRBTL3A6)#Kito
Transgene Detail
Nomenclature
Symbol: Tg(TRATL3A6,TRBTL3A6)#Kito
Name: transgene insertion, Kouichi Ito
MGI ID: MGI:5635436
Synonyms: TL3A6
Transgene: Tg(TRATL3A6,TRBTL3A6)#Kito  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TRATL3A6,TRBTL3A6)#Kito expresses 2 genes
 
Mutation detailsThis transgene expresses a Multiple Sclerosis patient-derived HLA DRB5*01:01-restricted myelin basic protein (83-99) specific TCR (TCR alpha and beta chains of the TL3A6 TCR). TL3A6 expresses Valpha9.2-Jalpha12-Calpha and Vbeta5.1-D-Jbeta1.2-Cbeta. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:189816)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:189816 Quandt JA, et al., Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. J Immunol. 2012 Sep 15;189(6):2897-908
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory