Ip6k2^tm1.1Snyd
Targeted Allele Detail

Summary

• Symbol: Ip6k2^tm1.1Snyd
• Name: inositol hexaphosphate kinase 2; targeted mutation 1.1, Solomon Snyder
• MGI ID: MGI:5635272
• Synonyms: Ip6k2^-
• Gene: Ip6k2 Location: Chr9:108660995-108683536 bp, + strand Genetic Position: Chr9, 59.63 cM, cytoband F2
• Alliance: Ip6k2^tm1.1Snyd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:212482
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 6. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 6. Cre-mediated recombination removed exon 6 and the selection cassette. Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts. (J:212482)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ip6k2 Mutation: 25 strains or lines available

References

• Original: J:212482 Rao F, et al., Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2. Mol Cell. 2014 Apr 10;54(1):119-32
• All: 4 reference(s)