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Prlhtm2Smln
Targeted Allele Detail
Nomenclature
Symbol: Prlhtm2Smln
Name: prolactin releasing hormone; targeted mutation 2, Simon M Luckman
MGI ID: MGI:5634278
Synonyms: LSL-PrRP
Gene: Prlh  Location: Chr1:90953108-90954027 bp, + strand  Genetic Position: Chr1, 45.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:215557
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA floxed STOP and neomycin resistance cassette were inserted upstream of the endogenous gene. Immunostaining confirmed the absence of protein expression in the brain. (J:215557)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prlh Mutation:  1 strain or line available
References
Original:  J:215557 Dodd GT, et al., The thermogenic effect of leptin is dependent on a distinct population of prolactin-releasing peptide neurons in the dorsomedial hypothalamus. Cell Metab. 2014 Oct 7;20(4):639-49
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory