Myh7^{tm1(EGFP/cre/ERT2)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Myh7^{tm1(EGFP/cre/ERT2)Wtsi}
• Name: myosin, heavy polypeptide 7, cardiac muscle, beta; targeted mutation 1, Wellcome Trust Sanger Institute
• MGI ID: MGI:5633809
• Synonyms: Myh7^{tm1(EGFP/cre/ERT2)Hmgu}
• Gene: Myh7 Location: Chr14:55208141-55232083 bp, - strand Genetic Position: Chr14, 28.01 cM
• Alliance: Myh7^{tm1(EGFP/cre/ERT2)Wtsi} page

Mutation origin

• Mutant Cell Line: CEPD0054_3_B02
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMMTOOLS

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutation: Insertion
• Myh7^{tm1(EGFP/cre/ERT2)Wtsi} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh7 (MGI:2155600)

• Mutation details: According to the allele molecular image presented by the International Knockout Mouse Consortium, this allele has loxP sites flanking exon 26, and inserted into the intron between exons 25 and 26 is one FRT site, an engrailed 2 splice acceptor sequence, an EGFP and cre/ERT2 expression cassette, and a Rox flanked puromycin resistance cassette. (J:155845)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Myh7 (mouse) Summary of all recombinase alleles driven by Myh7. Alliance mouse Myh7 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myh7 Mutation: 95 strains or lines available

References

• Original: J:155845 Wellcome Trust Sanger Institute, Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute. MGI Direct Data Submission. 2010
• All: 2 reference(s)