Tnfrsf11a^tm1.1Irw
Targeted Allele Detail

Summary

• Symbol: Tnfrsf11a^tm1.1Irw
• Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator; targeted mutation 1.1, Ifor R Williams
• MGI ID: MGI:5629957
• Synonyms: RANK^F, RANK^FL
• Gene: Tnfrsf11a Location: Chr1:105708443-105775709 bp, + strand Genetic Position: Chr1, 49.7 cM
• Alliance: Tnfrsf11a^tm1.1Irw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:219915
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were floxed. Flp-mediated recombination removed the FRT-flanked selection cassette inserted upstream of exon 2. (J:219915)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf11a Mutation: 42 strains or lines available

References

• Original: J:219915 Powell JJ, et al., An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells. Nat Nanotechnol. 2015 May;10(4):361-9
• All: 13 reference(s)