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Targeted Allele Detail
Symbol: Ntrk1tm1.1Azmo
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Aziz Moqrich
MGI ID: MGI:5621022
Synonyms: TrkAC-KI, TrkATrkAC
Gene: Ntrk1  Location: Chr3:87778244-87795162 bp, - strand  Genetic Position: Chr3, 38.62 cM
Peripheral, but not central innervation is drastically reduced in Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:210892
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
Mutation detailsExon 10 was modified to contain the Ntrk3 coding sequence for the transmembrane and intracellular regions (amino acids 431-824), IRES, Cherry reporter, polyadenylation sequence and floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. The protein product is a fusion of the extracellular region of Ntrk1 with the transmembrane and intracellular regions of Ntrk3. (J:210892)
Generation of the Ntrk1tm1.1Azmo allele
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  12 strains or lines available
Original:  J:210892 Gorokhova S, et al., Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. PLoS Genet. 2014 Feb;10(2):e1004081
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory