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Ntrk1tm1.1Azmo
Targeted Allele Detail
Nomenclature
Symbol: Ntrk1tm1.1Azmo
Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 1.1, Aziz Moqrich
MGI ID: MGI:5621022
Synonyms: TrkAC-KI, TrkATrkAC
Gene: Ntrk1  Location: Chr3:87778244-87795162 bp, - strand  Genetic Position: Chr3, 38.62 cM
Peripheral, but not central innervation is drastically reduced in Ntrk1tm1.1Azmo/Ntrk1tm1.1Azmo mice

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:210892
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsExon 10 was modified to contain the Ntrk3 coding sequence for the transmembrane and intracellular regions (amino acids 431-824), IRES, Cherry reporter, polyadenylation sequence and floxed neomycin resistance cassette. Cre-mediated recombination removed the selection cassette. The protein product is a fusion of the extracellular region of Ntrk1 with the transmembrane and intracellular regions of Ntrk3. (J:210892)
Generation of the Ntrk1tm1.1Azmo allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ntrk1 Mutation:  12 strains or lines available
References
Original:  J:210892 Gorokhova S, et al., Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor. PLoS Genet. 2014 Feb;10(2):e1004081
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory