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Ap1s2tm1Pschu
Targeted Allele Detail
Nomenclature
Symbol: Ap1s2tm1Pschu
Name: adaptor-related protein complex 1, sigma 2 subunit; targeted mutation 1, Peter Schu
MGI ID: MGI:5620801
Synonyms: sigma1B-
Gene: Ap1s2  Location: ChrX:162692013-162716662 bp, + strand  Genetic Position: ChrX, 75.97 cM, cytoband F5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:218588
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Modified isoform(s))
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced part of exon 3. This allele targets the sigma1B isoform. Northern-blot analysis confirmed the absence of transcript in mutant mouse embryonic fibroblasts. (J:218588)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ap1s2 Mutation:  7 strains or lines available
References
Original:  J:218588 Glyvuk N, et al., AP-1/sigma1B-adaptin mediates endosomal synaptic vesicle recycling, learning and memory. EMBO J. 2010 Apr 21;29(8):1318-30
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory