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Targeted Allele Detail
Symbol: Flnbtm1Vshn
Name: filamin, beta; targeted mutation 1, Volney Sheen
MGI ID: MGI:5620800
Synonyms: Flnb-
Gene: Flnb  Location: Chr14:14518185-14651816 bp, - strand  Genetic Position: Chr14, 4.59 cM
Premature differentiation within the prehypertrophic zone in the long bone growth plates of Flnbtm1Vshn/Flnbtm1Vshn mice

Show the 6 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:125095
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExons 3-5 were replaced by a neo selection cassette causing a frame shift mutation. Western blot analysis of P7 livers confirmed graded loss of protein expression in heterozygous and homozygous mutant mice. (J:125095)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 19 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Flnb Mutation:  163 strains or lines available
Original:  J:125095 Lu J, et al., Filamin B mutations cause chondrocyte defects in skeletal development. Hum Mol Genet. 2007 Jul 15;16(14):1661-75
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory