Trim28^chatwo
Chemically induced Allele Detail

Summary

• Symbol: Trim28^chatwo
• Name: tripartite motif-containing 28; chatwo
• MGI ID: MGI:5620610
• Gene: Trim28 Location: Chr7:12758079-12764959 bp, + strand Genetic Position: Chr7, 7.73 cM, cytoband A2
• Alliance: Trim28^chatwo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Hypomorph)
• Mutation: Nucleotide substitutions
• Mutation details: ENU mutagenesis induced two adjacent point mutations (CC>GA) that result in the amino acid substitutions of cysteine with tryptophan at position 713 and histidine with asparagine at position 714 (p.(Cys713_His714delinsTrpAsn)). (J:178936)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim28 Mutation: 33 strains or lines available

References

• Original: J:178936 Shibata M, et al., TRIM28 is required by the mouse KRAB domain protein ZFP568 to control convergent extension and morphogenesis of extra-embryonic tissues. Development. 2011 Dec;138(24):5333-43
• All: 2 reference(s)