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Chrna7tm1.1Ehs
Targeted Allele Detail
Nomenclature
Symbol: Chrna7tm1.1Ehs
Name: cholinergic receptor, nicotinic, alpha polypeptide 7; targeted mutation 1.1, National Institute of Environmental Health Science
MGI ID: MGI:5620283
Synonyms: alpha7flox, alpha7nAChRflox
Gene: Chrna7  Location: Chr7:62748440-62862274 bp, - strand  Genetic Position: Chr7, 34.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:219327
Parent Cell Line:  ART B6-3, B6-3 (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsThe targeting vector contains a loxP site 290 bp upstream of exon 4 and loxP site followed by a FRT-flanked PGK-Neo selection cassette 380 bp downstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette leaving exon 4 floxed. (J:219327)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chrna7 Mutation:  34 strains or lines available
References
Original:  J:219327 Hernandez CM, et al., Research tool: Validation of floxed alpha7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches. J Physiol. 2014 Aug 1;592(Pt 15):3201-14
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory