Il23r^tm1.1Ngh
Targeted Allele Detail

Summary

• Symbol: Il23r^tm1.1Ngh
• Name: interleukin 23 receptor; targeted mutation 1.1, Nico Ghilardi
• MGI ID: MGI:5619109
• Synonyms: IL-23R^-
• Gene: Il23r Location: Chr6:67399916-67468839 bp, - strand Genetic Position: Chr6, 30.85 cM
• Alliance: Il23r^tm1.1Ngh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216867
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A GFP reporter and a floxed neomycin selection cassette replaced exons 1 through 3. This removed the ATG start site, the signal peptide, and the Ig-like ligand binding domain. The cytokine receptor domain is retained. Cre recombination removed the neo selection cassette. (J:216867)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il23r Mutation: 68 strains or lines available

References

• Original: J:216867 Cox JH, et al., Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice. Mucosal Immunol. 2012 Jan;5(1):99-109
• All: 5 reference(s)