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Slc7a5tm1.2Daca
Targeted Allele Detail
Nomenclature
Symbol: Slc7a5tm1.2Daca
Name: solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; targeted mutation 1.2, Doreen A Cantrell
MGI ID: MGI:5618524
Gene: Slc7a5  Location: Chr8:121881146-121907686 bp, - strand  Genetic Position: Chr8, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:213820
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe targeting vector contains loxP sites flanking exon 1, including the initiation codon. An FRT-flanked neomycin resistance (neo) cassette fused to an internal ribosomal entry site (IRES) and a splice donor (SD) sequence, followed by a third loxP site, are placed downstream of exon 1. Flp-mediated recombination removed the FRT-flanked neo-IRES-SD cassette. Cre-mediated recombination removed exon1. (J:213820)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 54993 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc7a5 Mutation:  5 strains or lines available
References
Original:  J:213820 Poncet N, et al., The catalytic subunit of the system L1 amino acid transporter (slc7a5) facilitates nutrient signalling in mouse skeletal muscle. PLoS One. 2014;9(2):e89547
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory